Serum level of interleukin: 8 in correlation with aplastic anemia severity

Background: Aplastic anemia (AA) is a disease in which the bone marrow (BM) and hematopoietic stem cells are damaged causing pancytopenia. It may be hereditary or acquired it can range from mild to severe. Interleukin-8 (IL-8) chemokine that critical for tissue damage acute inflammation has been shown potent inhibitors of myelopoiesis. Interleukin promotes macrophages produce IL-8 AA. The aim present work was evaluate level patients with AA its correlation severity disease.Methods: study conducted on 40 individuals, 30 newly diagnosed 10 healthy subjects served as control. They classified group I (8 very severe 20%), II (16 40%), III (6 non-severe 15%) IV (10 apparently individuals control). All groups were subjected complete blood count (CBC), BM aspiration biopsy only, erythrocyte sedimentation rate (ESR) lactate dehydrogenase (LDH), measuring serum by enzyme-linked immunosorbent assay (ELISA).Results: Serum levels significantly higher at diagnosis when compared normal controls. A significant negative found between Hb level, platelets count, neutrophil reticulocyte cellularity, also positive ESR.Conclusion: Level than patients, suggested involved mechanisms hence correlates progression.